Clinical appraisal of intra-arterial priscoline therapy in the management of peripheral arterial diseases.

Priscoline can be given intra-arterially without difficulty. Untoward reactions are infrequent even in older patients. Intra-arterial administration was often effective in patients who did not respond to oral Priscoline. Although maximal vasodilatation may not be achieved by giving Priscoline intra-arterially, the degree of vasodilatation obtained is often adequate for a clinical effect. Results in 250 patients indicate that intra-arterial Priscoline is most useful in the treatment of ischemic rest pain resulting from organic vascular disease. Improvement in exercise tolerance was infrequent. Causalgia, delayed wound healing and ulceration in Reynaud's disease responded favorably in some instances.